A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters시리아 골든 햄스터에서 SARS-CoV-2 Omicron BA.1(B.1.1.529) 변종 접종 후 폐 병변Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] animals B.1.1.529 B.1.617.2 characterized Clinical signs COVID-19 disease decrease Delta Disease progression disease severity evaluate Evidence evidence of golden hamster hamster hamsters histopathological Human Immune escape Immunity Infection inoculated intrinsic Kinetics lesion Mutation omicron Omicron BA.1 pathogenicity pathological changes pathology Pneumonia pre-existing immunity progression pulmonary re-challenge. reduced SARS-CoV-2 SARS-CoV-2 variant Syrian golden hamster the SARS-CoV-2 vaccination variant viral genome viral shedding viral spread virus [DOI] 10.1080/22221751.2022.2095932 PMC 바로가기 [Article Type] Article
COVID-19 and inflammatory bowel disease crosstalk: From emerging association to clinical proposalArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] abdominal pain ACE2 acute respiratory syndrome addition association Autoimmune bowel Care caused coronavirus coronavirus disease COVID-19 COVID-19 epidemic diarrhea disease downregulated enzyme Epidemic etiology exacerbate expressed feasibility Genetic IBD IL-17 Imbalance immune activation immunosuppressive drug increase induce Infection Inflammatory Inflammatory bowel disease inflammatory bowel disease. inflammatory disease Inflammatory response intestinal intestinal inflammation intestine lung mechanism nonspecific overlapping pathway Patient patients Pneumonia progression protective factor receptor Research respiratory inflammation risk risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection Symptom systemic symptom the cytokine storm the SARS-CoV-2 Treatment upregulated vaccination [DOI] 10.1002/jmv.28067 PMC 바로가기
COVID-19: imbalanced cell-mediated immune response drives to immunopathologyArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome alveolar damage Antiviral caused cell-mediated immune cell-mediated immune response changes in consequence coronavirus coronavirus disease COVID-19 Critical cytokine Cytokine storm effective Endotheliitis exacerbated excessive inflammation fluid overload homeostasis Host host cells immune immune responses immune system Immunological response immunopathology Inflammatory response Invasion involved lung damage Lung injury manifested mechanism NETs neutrophil activation organs pandemic Pathogenesis pathogenesis. pathophysiological progression SARS-CoV-2 SARS-CoV-2-specific immune responses severe disease syndrome therapeutic agent Therapeutic strategies tissue Trigger viral infection [DOI] 10.1080/22221751.2022.2122579 PMC 바로가기
Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic controlResearch article Published on 2022-12-012022-10-05 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 analysed antagonistic autophagy caused Cell cellular metabolism cellular processe Course COVID-19 death Disease progression enzyme Epigenetic epigenetics example expression profile function genes encoding Genome Host host cell IL-6 Infection investigated Laboratory Lipid mechanism membrane metabolic activity metabolic pathway methionine pathogen invasion patients Perspective progression rDNA Regulation replication mechanism ribosome S-adenosylmethionine SARS-CoV-2 sera social isolation the disease the patient therapeutic therapy tissue viral loads virus virus particle virus replication [DOI] 10.1016/j.bbadis.2022.166527 [Article Type] Research article
Clinical microbiology in detection and identification of emerging microbial pathogens: past, present and futureArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] 진단, [키워드] Antibody assays Antigen Bacterial pathogens change clinical clinical microbiology Clinical practice COVID-19 COVID-19 pandemic Critical Culture Diagnosis diagnostics Diseases evidenced Genomics Gram stain IMPROVE in vitro Infectious disease metabolomics microbial microbial infections Molecular biology MONITOR morphology nucleic acid nucleic acid amplification outcome pathogen detection Patient point of care progression proteomics Revolutionary transcriptomics transcriptomics. [DOI] 10.1080/22221751.2022.2125345 PMC 바로가기
Can torque teno virus be a predictor of SARS-CoV-2 disease progression in cancer patients?Article Published on 2022-12-012022-11-15 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 치료기술, [키워드] analysed association Can Cancer cancer patient Cancer patients clinical manifestation Control control subjects controls correlation COVID-19 death deficiency demonstrated detectable died DNA immune system indicated Infection Nasopharyngeal swab outcomes patients with SARS-CoV-2 previous study progression Retrospective study SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 RNA SARS-CoV-2-positive patients significantly lower statistically significant subjects survival rate torque Torque teno virus. Viral load virus was related [DOI] 10.1016/j.jiac.2022.08.015 PMC 바로가기
The impact of an enhanced health surveillance system for COVID-19 management in Serrana, BrazilResearch article Published on 2022-12-012022-10-05 Journal: Public Health in Practice [Category] 진단, [키워드] Brazil Clinical characteristics collected Community conducted cough COVID-19 COVID-19 patients COVID-19 research develop diabetes died disease disease severity epidemiological Evolution Follow-up headache Health Hospitalized hypertension implementation IQR management median age men Mild moderate disease MONITOR myalgia objective participant Patient patients Personal protective equipment positive progression prospective observational cohort public health public health surveillance Research Result SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 positivity SARS-CoV-2 RNA Seven severe disease state study period Support Surveillance Swab Symptom the epidemic variants was increased were assessed women World Health Organization [DOI] 10.1016/j.puhip.2022.100301 [Article Type] Research article
Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort studyArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료기술, [키워드] advanced age age Cancer China Chronic kidney disease CKD cohort study Comorbidity condition conditions COVID-19 critical cases enrolled Factor female first positive hospialized population Hospitalized hospitalized patient hypertension identification Logistic regression Metabolic disorders multivariate Observational cohort study omicron participant Patient patients Primary outcome Prognosis progression risk factor Risk factors Risk factors. SARS-CoV-2 SARS-CoV-2 detection secondary outcome severity Shanghai suggested vaccination viral shedding [DOI] 10.1080/22221751.2022.2122581 PMC 바로가기
Humoral and Cellular Immune Response to Covid-19 Vaccination in Patients with Chronic Graft-versus-Host Disease on ImmunosuppressionArticle Published on 2022-11-012022-11-15 Journal: Transplantation and cellular therapy [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome amplified anti-spike antibody antibody association cellular Characteristics chronic coronavirus COVID-19 COVID-19 vaccination demonstrated detect disease dose Efficacy enrolled Escalation evaluated group HCT humoral Humoral response immune immune response Immunosuppression immunosuppressive immunosuppressive therapy Infection initial management mononuclear cell natural infection neutralizing antibody Neutralizing antibody response neutralizing antibody titers Patient patient population patients Peripheral blood positive positive correlation present progression proportion Quantitative receiving Responder responders response Sample size SARS-CoV-2 sequence Significant statistical difference susceptibility T cell T cell receptor T cell response T cell responses the antibody response the patient therapy unique vaccination Vaccine vaccine. was measured were measured worsened worsening [DOI] 10.1016/j.jtct.2022.08.026 PMC 바로가기